A basic synthesis of deli pickle and green pesto sauce have some amazing cancer fighting antioxidants which can be used in potential chemotherapeutic agents, according to a team of scientists from the Moscow Institute of Physics and Technology (MIPT) and
Since chemotherapy regimens target rapidly dividing cancer cells using antimitotic agents that inhibit the growth of these cells by disrupting the process of cell division. Cancer cells divide much more frequently than normal cells and incidentally, they are more susceptible to antimitotics, leading to the disruption of the cell cycle and ultimately cell death.
In their study, the Russian researchers developed a synthesis of the potent antimitotic agent glaziovianin A (GVA), isolated from the leaves of the Brazilian tree Ateleia glazioviana Baill. As the synthesis of GVA is rather laborious, requiring expensive precursors and catalysts, they proposed a new six-stage synthesis process for GVA and the synthesis was derived from the seeds of parsley and dill.
“Both improvement of existing therapies and search for innovative approaches are essential components of a quest to treat cancer,” said MIPT adjunct professor Alexander Kiselev.
The findings were published in the Journal of Natural Products. In addition to GVA, they synthesized a number of its structural analogs with favorable antimitotic properties. The antitumor activity was tested via two independent methods using the sea urchin embryos and human cancer cells.
The Russian team added test substances to an aqueous medium with the embryos to determine the concentrations at which the rate of division changes and when it comes to a complete stop. Using the embryos, they were able to determine several critical parameters for an anticancer molecule. These included the specific antimitotic effect, solubility, overall toxicity, and biomembrane permeability.
To confirm the antitumor effect, they studied its effect on human cancer cells including lung carcinoma, melanoma, prostate, breast, colon, and ovarian cancers. The synthesis was effective at limiting the growth of melanoma cells and nontoxic to healthy blood cells used as a control. Detailed structure–activity relationship studies in both assay systems converged on GVA as being the most active antitubulin agent.